Causes of death of patients with laryngeal cancer

Eur Arch Otorhinolaryngol. 2014 Mar;271(3):425-34. doi: 10.1007/s00405-013-2478-0. Epub 2013 Apr 17.


Despite remarkable advances in the care of patients with laryngeal cancer over the past several decades, including a growing awareness of therapeutic complications and attention to quality of life, little is known about the causes of mortality in this population. In addition to the laryngeal malignancy itself, acute and late or chronic treatment-associated causes, second primary cancers, intercurrent disease and psychosocial factors are all responsible for patient morbidity and mortality. We examine the current literature related to the causes of death in patients with laryngeal cancer, in the hope of guiding future interventions to improve the longevity and quality of life of individuals with this cancer.

Publication types

  • Review

MeSH terms

  • Carcinoma, Squamous Cell / mortality*
  • Cause of Death
  • Head and Neck Neoplasms / mortality*
  • Humans
  • Laryngeal Neoplasms / mortality*
  • Neoplasm Recurrence, Local / mortality*
  • Neoplasms, Second Primary / mortality*
  • Squamous Cell Carcinoma of Head and Neck
  • Suicide / statistics & numerical data*
  • Treatment Refusal / statistics & numerical data