Expression pattern of Nogo-A, MAG, and NgR in regenerating urodele spinal cord

Dev Dyn. 2013 Jul;242(7):847-60. doi: 10.1002/dvdy.23976. Epub 2013 Jun 3.


Background: The mammalian central nervous system is incapable of substantial axon regeneration after injury partially due to the presence of myelin-associated inhibitory molecules including Nogo-A and myelin associated glycoprotein (MAG). In contrast, axolotl salamanders are capable of considerable axon regrowth during spinal cord regeneration.

Results: Here, we show that Nogo-A and MAG, and their receptor, Nogo receptor (NgR), are present in the axolotl genome and are broadly expressed in the central nervous system (CNS) during development, adulthood, and importantly, during regeneration. Furthermore, we show that Nogo-A and NgR are co-expressed in Sox2 positive neural progenitor cells.

Conclusions: These expression patterns suggest myelin-associated proteins are permissive for neural development and regeneration in axolotls.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ambystoma mexicanum / metabolism*
  • Amphibian Proteins / genetics
  • Amphibian Proteins / metabolism*
  • Animals
  • Myelin Proteins / genetics
  • Myelin Proteins / metabolism*
  • Myelin-Associated Glycoprotein / genetics
  • Myelin-Associated Glycoprotein / metabolism*
  • Nogo Proteins
  • Spinal Cord Injuries / genetics
  • Spinal Cord Injuries / metabolism*
  • Spinal Cord Regeneration / genetics
  • Spinal Cord Regeneration / physiology*


  • Amphibian Proteins
  • Myelin Proteins
  • Myelin-Associated Glycoprotein
  • Nogo Proteins