Using partial least squares regression to analyze cellular response data

Sci Signal. 2013 Apr 16;6(271):tr7. doi: 10.1126/scisignal.2003849.


This Teaching Resource provides lecture notes, slides, and a problem set for a lecture introducing the mathematical concepts and interpretation of partial least squares regression (PLSR) that were part of a course entitled "Systems Biology: Mammalian Signaling Networks." PLSR is a multivariate regression technique commonly applied to analyze relationships between signaling or transcriptional data and cellular behavior.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Cell Physiological Phenomena / physiology*
  • Least-Squares Analysis*
  • Models, Biological*
  • Signal Transduction / physiology*
  • Systems Biology / methods*
  • Teaching Materials*