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. 2013;9(4):e1003227.
doi: 10.1371/journal.ppat.1003227. Epub 2013 Apr 4.

Parasites FeS up: iron-sulfur cluster biogenesis in eukaryotic pathogens

Teegan A Dellibovi-Ragheb  1 , Jolyn E Gisselberg, Sean T Prigge
Affiliations

Parasites FeS up: iron-sulfur cluster biogenesis in eukaryotic pathogens

Teegan A Dellibovi-Ragheb et al. PLoS Pathog. 2013.
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. FeS cluster biogenesis pathways in eukaryotic pathogens.
Eukaryotic pathogens contain an ISC (Iron-Sulfur Cluster formation) pathway in the mitochondrion or mitochondrion-like organelle (MLO), a CIA (Cytosolic Iron-sulfur protein Assembly) pathway in the cytosol, and plastid-containing organisms such as Plasmodium have the SUF (SUlFur mobilization) pathway in this organelle. FeS cluster biogenesis is absolutely essential in mitochondria and MLOs, and is likely the driving force for retention of these organelles. Entamoeba is the exception that proves the rule: it has dispensed with the ISC machinery, but replaced it with a bacterial NIF (NItrogen Fixation) pathway acquired by lateral gene transfer that appears to fulfill the requirement for FeS cluster synthesis in the mitosome.
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