Horizontal ridge augmentation with a collagen membrane and a combination of particulated autogenous bone and anorganic bovine bone-derived mineral: a prospective case series in 25 patients

Int J Periodontics Restorative Dent. May-Jun 2013;33(3):299-307. doi: 10.11607/prd.1407.


This prospective case series evaluated the use of a resorbable natural collagen membrane with a mixture of autogenous bone and anorganic bovine bone-derived mineral (ABBM) for lateral ridge augmentation and subsequent implant placement. A mixture (1:1) of particulated autogenous bone and ABBM was used for lateral ridge augmentation and covered with a resorbable, natural collagen bilayer membrane to treat knife-edge ridges and prepare them for implant placement. Ridge measurements were obtained pre- and postsurgery, complications recorded, and biopsy specimens examined histologically. Seventy-six implants were placed in 25 patients with 31 knife-edge ridge surgical sites. One defect had a bone graft complication (3.2%; exact 95% confidence interval: 0.1%, 16.7%). Clinical measurements revealed an average of 5.68 mm (standard deviation [SD] = 1.42 mm) of lateral ridge augmentation after a mean 8.9-month (SD = 2.1 months) graft healing period. Clinically, all treated ridges were sufficient in width for subsequent implant placement. All implants survived with an average follow-up of 20.88 months (SD = 9.49 months). Histologic analysis of nine surgical sites showed that ABBM was connected with a dense network of newly formed bone with varying degrees of maturation. Histomorphometric analysis demonstrated that autogenous bone represented a mean of 31.0% of the specimens, ABBM 25.8%, and marrow space 43.2%. The treatment of horizontally deficient alveolar ridges with the guided bone regeneration technique using autogenous bone mixed with ABBM and a natural collagen resorbable barrier membrane can be regarded as successful. Implant success and survival need to be confirmed with long-term follow-up examinations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorbable Implants
  • Adult
  • Aged
  • Alveolar Ridge Augmentation / methods*
  • Autografts / pathology
  • Autografts / transplantation*
  • Bone Marrow / pathology
  • Bone Regeneration / physiology
  • Bone Substitutes / therapeutic use*
  • Bone Transplantation / methods*
  • Collagen*
  • Dental Implantation, Endosseous
  • Female
  • Follow-Up Studies
  • Graft Survival
  • Guided Tissue Regeneration, Periodontal / methods
  • Humans
  • Male
  • Mandible / pathology
  • Mandible / surgery
  • Maxilla / pathology
  • Maxilla / surgery
  • Membranes, Artificial*
  • Middle Aged
  • Minerals / therapeutic use
  • Osteogenesis / physiology
  • Prospective Studies
  • Survival Analysis
  • Treatment Outcome


  • Bio-Gide
  • Bio-Oss
  • Bone Substitutes
  • Membranes, Artificial
  • Minerals
  • Collagen