Molecular mechanisms underlying RB protein function

Nat Rev Mol Cell Biol. 2013 May;14(5):297-306. doi: 10.1038/nrm3567. Epub 2013 Apr 18.


Inactivation of the RB protein is one of the most fundamental events in cancer. Coming to a molecular understanding of its function in normal cells and how it impedes cancer development has been challenging. Historically, the ability of RB to regulate the cell cycle placed it in a central role in proliferative control, and research focused on RB regulation of the E2F family of transcription factors. Remarkably, several recent studies have found additional tumour-suppressor functions of RB, including alternative roles in the cell cycle, maintenance of genome stability and apoptosis. These advances and new structural studies are combining to define the multifunctionality of RB.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis / genetics
  • Cell Cycle / genetics
  • Genomic Instability
  • Humans
  • Retinoblastoma Protein / genetics*
  • Retinoblastoma Protein / metabolism*


  • Retinoblastoma Protein

Associated data

  • PDB/1GUX
  • PDB/1N4M
  • PDB/2AZE
  • PDB/2QDJ