[Intraoperative chemotherapy after radical pleurectomy or extrapleural pneumonectomy]

Chirurg. 2013 Jun;84(6):492-6. doi: 10.1007/s00104-012-2433-4.
[Article in German]

Abstract

Trimodality treatment including induction and/or adjuvant chemotherapy, surgical resection and in some cases radiotherapy offers a curative intention in selected patients with pleural malignancies (malignant pleural mesothelioma, thymoma with pleural spread). Nevertheless, locoregional tumor recurrence mainly limits the outcome and the quality of life. A few years ago an additional intraoperative chemotherapy perfusion was developed in order to improve local tumor control and prognosis after surgical resection in a multimodality treatment setting. Cytoreductive surgery with the purpose of a macroscopic complete resection could be achieved by radical pleurectomy or extrapleural pneumonectomy. The concept, techniques and perioperative management of this additional treatment option are presented along with a detailed review of the recent literature.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Chemotherapy, Adjuvant
  • Chemotherapy, Cancer, Regional Perfusion / methods*
  • Cisplatin / administration & dosage
  • Cisplatin / adverse effects
  • Combined Modality Therapy*
  • Critical Care / methods
  • Humans
  • Hyperthermia, Induced / methods*
  • Intraoperative Period
  • Pleura / pathology
  • Pleura / surgery*
  • Pleural Neoplasms / drug therapy*
  • Pleural Neoplasms / pathology
  • Pleural Neoplasms / secondary
  • Pleural Neoplasms / surgery*
  • Pneumonectomy / methods*
  • Postoperative Care / methods
  • Postoperative Complications / etiology
  • Postoperative Complications / mortality
  • Survival Rate
  • Thymoma / drug therapy
  • Thymoma / pathology
  • Thymoma / secondary
  • Thymoma / surgery
  • Thymus Neoplasms / drug therapy
  • Thymus Neoplasms / pathology
  • Thymus Neoplasms / surgery

Substances

  • Cisplatin