Influence of clinical breakpoint changes from CLSI 2009 to EUCAST 2011 antimicrobial susceptibility testing guidelines on multidrug resistance rates of Gram-negative rods

Michael Hombach; Aline Wolfensberger; Stefan P Kuster; Erik C Böttger

doi:10.1128/JCM.00921-13

Influence of clinical breakpoint changes from CLSI 2009 to EUCAST 2011 antimicrobial susceptibility testing guidelines on multidrug resistance rates of Gram-negative rods

J Clin Microbiol. 2013 Jul;51(7):2385-7. doi: 10.1128/JCM.00921-13. Epub 2013 Apr 17.

Authors

Michael Hombach¹, Aline Wolfensberger, Stefan P Kuster, Erik C Böttger

Affiliation

¹ Institut für Medizinische Mikrobiologie, Universität Zürich, Zürich, Switzerland. mhombach@imm.uzh.ch

Abstract

Multidrug resistance (MDR) rates of Gram-negative rods were analyzed comparing CLSI 2009 and EUCAST 2011 antibiotic susceptibility testing guidelines. After EUCAST 2011 was applied, the MDR rates increased for Klebsiella pneumoniae (2.2%), Enterobacter cloacae (1.1%), Pseudomonas aeruginosa (0.7%), and Escherichia coli (0.4%). A total of 24% of Enterobacteriaceae MDR isolates and 12% of P. aeruginosa MDR isolates were categorized as MDR due to breakpoint changes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Resistance, Multiple, Bacterial*
Gram-Negative Bacteria / drug effects*
Gram-Negative Bacteria / isolation & purification
Gram-Negative Bacterial Infections / epidemiology
Gram-Negative Bacterial Infections / microbiology*
Humans
Microbial Sensitivity Tests / methods*
Microbial Sensitivity Tests / standards
Prevalence