Investigation of chemical compounds, antioxidant and antimicrobial properties of teucrium arduini L. (lamiaceae)

Curr Drug Targets. 2013 Aug;14(9):1006-14. doi: 10.2174/1389450111314090009.


In this paper chemical composition of the essential oil (analysed by GC and GC-MS), the content of phenolic compounds (analysed by HPLC), quantity of total phenols and total flavonoids (analysed by UV/Vis spectrophotometer), antioxidant and antimicrobial activities of ethanolic extracts were investigated in endemic Teucrium arduini L. in population of Mt Biokovo (Croatia). The oil was characterized by a high concentration of sesquiterpene hydrocarbons (70.4%) of which β-caryophyllene (35.2%) and germacrene D (18.7%) being the major compounds. Three phenolic compounds (quercetin, ferulic acid and rosmarinic acid) were identified and quantified in ethanolic extract of T. arduini using HPLC. The results also showed that T. arduini is a source of polyphenolic and other antioxidants with radical-scavenging and chelating properties. The ethanol extracts prepared from the leaf of T. arduini showed broad spectrum of antimicrobial activity on Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans and Aspergillus brasiliensis, which are susceptible on concentration below or equal to 4.00 mg/mL, whilst Microsporum gypseum was resistant at investigated concentrations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents / analysis
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / pharmacology*
  • Antioxidants / analysis
  • Antioxidants / chemistry
  • Antioxidants / pharmacology*
  • Bacteria / drug effects*
  • Chromatography, High Pressure Liquid
  • Cinnamates / analysis
  • Coumaric Acids / analysis
  • Croatia
  • Depsides / analysis
  • Ethanol
  • Fungi / drug effects*
  • Microsporum
  • Oils, Volatile / chemistry
  • Oils, Volatile / pharmacology*
  • Phenol / analysis
  • Phenol / isolation & purification
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Quercetin / analysis
  • Teucrium / chemistry*


  • Anti-Infective Agents
  • Antioxidants
  • Cinnamates
  • Coumaric Acids
  • Depsides
  • Oils, Volatile
  • Plant Extracts
  • teucrium extract
  • Phenol
  • Ethanol
  • Quercetin
  • ferulic acid
  • rosmarinic acid