SAPHO syndrome

Rheum Dis Clin North Am. 2013 May;39(2):401-18. doi: 10.1016/j.rdc.2013.02.009. Epub 2013 Mar 13.


SAPHO syndrome is a disorder characterized by Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis. As the osteoarticular and skin manifestations often do not occur simultaneously and there are no validated diagnostic criteria, the diagnosis can be difficult. Clinical and imaging investigation is necessary to establish the many differential diagnoses of SAPHO syndrome. The etiopathogenesis involves infectious (probably Propionibacterium acnes), immunologic, and genetic factors. Treatment is based on information gathered from case reports and small series, and is related to specific skin or articular symptoms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acne Vulgaris / pathology
  • Acquired Hyperostosis Syndrome* / diagnosis
  • Acquired Hyperostosis Syndrome* / diagnostic imaging
  • Acquired Hyperostosis Syndrome* / epidemiology
  • Acquired Hyperostosis Syndrome* / therapy
  • Arthralgia / pathology
  • Causality
  • Humans
  • Hyperostosis / pathology
  • Joints / pathology
  • Musculoskeletal Diseases / pathology
  • Musculoskeletal Pain / pathology
  • Osteitis / pathology
  • Radiography
  • Rare Diseases
  • Skin / pathology
  • Synovitis / pathology