pH-sensitive poly(glutamic acid) grafted mesoporous silica nanoparticles for drug delivery

Int J Pharm. 2013 Jun 25;450(1-2):296-303. doi: 10.1016/j.ijpharm.2013.04.014. Epub 2013 Apr 15.

Abstract

pH-sensitive poly(L-glutamic acid) grafted mesoporous silica nanoparticles (MSN-PLGA) were prepared by the surface-initiated N-carboxyanhydride polymerization method. The resultant MSN-PLGA was well dispersed in aqueous medium and showed high drug loading efficiency, superior stability, and significantly higher drug release rates. The cumulative release of doxorubicin hydrochloride (DOX) from DOX-loaded MSN-PLGA (DOX@MSN-PLGA) was pH-dependent and the release rate was much higher at pH 5.5 than that at pH 7.4. The cytotoxicity results indicated that the blank MSN-PLGA was biocompatible and the DOX@MSN-PLGA had potent in vitro cytotoxicity effect similar to free DOX. Overall, these results demonstrate that MSN-PLGA is a promising platform to build pH controlled drug delivery systems for cancer therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibiotics, Antineoplastic / administration & dosage
  • Antibiotics, Antineoplastic / chemistry*
  • Cell Survival / drug effects
  • Doxorubicin / administration & dosage
  • Doxorubicin / chemistry*
  • Drug Delivery Systems
  • HeLa Cells
  • Humans
  • Hydrogen-Ion Concentration
  • Nanoparticles / administration & dosage
  • Nanoparticles / chemistry*
  • Osmolar Concentration
  • Particle Size
  • Polyglutamic Acid / chemistry*
  • Silicon Dioxide / chemistry*
  • Spectroscopy, Fourier Transform Infrared

Substances

  • Antibiotics, Antineoplastic
  • Polyglutamic Acid
  • Silicon Dioxide
  • Doxorubicin