Effects of selected bioactive natural products on the vascular endothelium

J Cardiovasc Pharmacol. 2013 Aug;62(2):111-21. doi: 10.1097/FJC.0b013e3182927e47.

Abstract

The endothelium, a highly active structure, regulates vascular homeostasis through the release of numerous vasoactive factors that control vascular tone and vascular smooth cell proliferation. A larger number of medicinal plants and their isolated chemical constituents have been shown to beneficially affect the endothelium. For example, flavonoids in black tea, green tea, and concord grape cause a vasodilation possibly through their antioxidant properties. Allicin, a by-product of the enzyme alliinase, has been proposed to be the main active metabolite and responsible for most of the biological activities of garlic, including a dose-dependent dilation on the isolated coronaries. Thymoquinone, the principal phytochemical compound found in the volatile oil of the black seed, and the hawthorn extract have also been shown to improve aging-related impairment of endothelium-dependent relaxations in animal models. In this review, the effect of some of the natural products, including Camellia sinensis (black tea and green tea), Vitis labrusca (concord grape), Allium sativum (garlic), and Nigella sativa (black seed) and Crataegus ssp (hawthorn extract), is explored. The molecular mechanisms behind these potential therapeutic effects are also discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Products / metabolism
  • Biological Products / therapeutic use
  • Cardiovascular Agents / metabolism
  • Cardiovascular Agents / therapeutic use*
  • Dietary Supplements*
  • Endothelium, Vascular / metabolism*
  • Endothelium, Vascular / physiopathology
  • Humans
  • Models, Biological*
  • Phytotherapy*
  • Plant Extracts / metabolism
  • Plant Extracts / therapeutic use*
  • Vascular Diseases / diet therapy
  • Vascular Diseases / metabolism
  • Vascular Diseases / physiopathology
  • Vascular Diseases / prevention & control*

Substances

  • Biological Products
  • Cardiovascular Agents
  • Plant Extracts