INstruct: a database of high-quality 3D structurally resolved protein interactome networks

Bioinformatics. 2013 Jun 15;29(12):1577-9. doi: 10.1093/bioinformatics/btt181. Epub 2013 Apr 18.


INstruct is a database of high-quality, 3D, structurally resolved protein interactome networks in human and six model organisms. INstruct combines the scale of available high-quality binary protein interaction data with the specificity of atomic-resolution structural information derived from co-crystal evidence using a tested interaction interface inference method. Its web interface is designed to allow for flexible search based on standard and organism-specific protein and gene-naming conventions, visualization of protein architecture highlighting interaction interfaces and viewing and downloading custom 3D structurally resolved interactome datasets.

Availability: INstruct is freely available on the web at with all major browsers supported.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Databases, Protein*
  • Humans
  • Mice
  • Protein Interaction Domains and Motifs*
  • Protein Interaction Mapping / methods*