[Preparation and application on compound excipient of sodium stearyl fumarate and plasdone S-630]

Yao Xue Xue Bao. 2013 Jan;48(1):125-30.
[Article in Chinese]


The compound excipient containing sodium stearyl fumarate and plasdone S-630 was prepared by applying spray drying method. The basic physical properties of compound excipient were studied by solubility test, scanning electron microscope, differential scanning calorimeter, X-ray diffraction and Fourier transform infra-red spectroscopy. The effect of compound excipient on moisture absorption and ferulic acid in vitro dissolution of spray drying power of angelica were investigated. The results showed that the chemical constituents of compound excipient did not change before and after spray drying. The water soluble compound excipient can improve significantly moisture absorption and has application prospect.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetates / chemistry*
  • Calorimetry, Differential Scanning
  • Coumaric Acids / administration & dosage
  • Coumaric Acids / chemistry*
  • Drug Compounding
  • Excipients / chemistry
  • Fumarates / chemistry*
  • Microscopy, Electron, Scanning
  • Particle Size
  • Povidone / analogs & derivatives*
  • Povidone / chemistry
  • Solubility
  • Spectroscopy, Fourier Transform Infrared
  • Surface Properties
  • Wettability
  • X-Ray Diffraction


  • Acetates
  • Coumaric Acids
  • Excipients
  • Fumarates
  • copolyvidonum Plasdone S-630
  • sodium stearyl fumarate
  • ferulic acid
  • Povidone