Comparison of the effect of human milk and topical hydrocortisone 1% on diaper dermatitis

Pediatr Dermatol. 2013 Nov-Dec;30(6):725-9. doi: 10.1111/pde.12118. Epub 2013 Apr 22.

Abstract

Diaper dermatitis is one of the most common skin problems in infants and children, affecting between 7% and 35% of infants. This randomized clinical trial compared the efficacy of hydrocortisone 1% ointment with that of human breast milk in treating acute diaper dermatitis in infants ages 0 to 24 months. Infants with diaper rash were treated with either hydrocortisone 1% ointment (n = 70) or human breast milk (n = 71) for 7 days. Improvement in the rash from baseline was seen in both treatment groups on days 3 and 7; there was no significant difference in total rash scores on days 3 and 7. Treatment with human breast milk was as effective as hydrocortisone 1% ointment alone. Human breast milk is an effective and safe treatment for diaper dermatitis in infants.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Anti-Inflammatory Agents / administration & dosage
  • Breast Feeding
  • Dermatitis / drug therapy*
  • Diaper Rash / drug therapy*
  • Humans
  • Hydrocortisone / administration & dosage*
  • Infant
  • Infant, Newborn
  • Milk, Human*
  • Severity of Illness Index
  • Skin / drug effects
  • Surveys and Questionnaires
  • Treatment Outcome

Substances

  • Anti-Inflammatory Agents
  • Hydrocortisone

Associated data

  • IRCT/IRCT201102163869N2