The impact of succimer chelation on blood cadmium in children with background exposures: a randomized trial

J Pediatr. 2013 Aug;163(2):598-600. doi: 10.1016/j.jpeds.2013.03.009. Epub 2013 Apr 16.


Succimer lowers blood lead concentrations in children, and the structure of succimer chelates of lead and cadmium are similar. Using blood samples from a randomized trial of succimer for lead poisoning, however, we found that succimer did not lower blood cadmium in children with background exposure.

Trial registration: NCT00342849.

Keywords: LOD; Limit of detection.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Intramural

MeSH terms

  • Cadmium / blood*
  • Chelating Agents / therapeutic use*
  • Chelation Therapy*
  • Child
  • Environmental Exposure / adverse effects*
  • Humans
  • Lead Poisoning / blood*
  • Lead Poisoning / drug therapy*
  • Succimer / therapeutic use*


  • Chelating Agents
  • Cadmium
  • Succimer

Associated data