Probing functional tyrosines

Chem Biol. 2013 Apr 18;20(4):457-8. doi: 10.1016/j.chembiol.2013.04.002.


Reactivity probes are small molecules that contain a reactive electrophile and a purification handle, and are used to identify hyperreactive amino acid residues within a whole proteome. In this issue of Chemistry & Biology, Gu et al. use sulfonyl fluoride derivatives for the identification of functional tyrosine residues in different classes of glutathione S-transferases.

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