Abstract
We evaluated two polymorphisms at CYP1A2 (*1C and *1F) in a sample of 108 European-derived patients with schizophrenia and their influence on the pro-convulsive effect of clozapine. We found the *1F/*1F genotype to be significantly associated with seizures, and no relationship was observed with combinations of *1F and *1C alleles.
Keywords:
Adverse effects; Cytochrome; Pharmacogenetics.
© 2013 Elsevier Ireland Ltd. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Antipsychotic Agents / adverse effects*
-
Brazil / epidemiology
-
Clozapine / adverse effects*
-
Cytochrome P-450 CYP1A2 / genetics*
-
Electroencephalography
-
Epilepsy, Tonic-Clonic / chemically induced*
-
Epilepsy, Tonic-Clonic / genetics*
-
Female
-
Genetic Association Studies
-
Genotype
-
Humans
-
Male
-
Polymorphism, Genetic*
-
RNA, Messenger
-
Schizophrenia / drug therapy
-
White People
Substances
-
Antipsychotic Agents
-
RNA, Messenger
-
Cytochrome P-450 CYP1A2
-
Clozapine