The CYP1A2 -163C>A polymorphism is associated with clozapine-induced generalized tonic-clonic seizures in Brazilian schizophrenia patients

Psychiatry Res. 2013 Sep 30;209(2):242-5. doi: 10.1016/j.psychres.2013.02.030. Epub 2013 Apr 18.

Abstract

We evaluated two polymorphisms at CYP1A2 (*1C and *1F) in a sample of 108 European-derived patients with schizophrenia and their influence on the pro-convulsive effect of clozapine. We found the *1F/*1F genotype to be significantly associated with seizures, and no relationship was observed with combinations of *1F and *1C alleles.

Keywords: Adverse effects; Cytochrome; Pharmacogenetics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antipsychotic Agents / adverse effects*
  • Brazil / epidemiology
  • Clozapine / adverse effects*
  • Cytochrome P-450 CYP1A2 / genetics*
  • Electroencephalography
  • Epilepsy, Tonic-Clonic / chemically induced*
  • Epilepsy, Tonic-Clonic / genetics*
  • Female
  • Genetic Association Studies
  • Genotype
  • Humans
  • Male
  • Polymorphism, Genetic*
  • RNA, Messenger
  • Schizophrenia / drug therapy
  • White People

Substances

  • Antipsychotic Agents
  • RNA, Messenger
  • Cytochrome P-450 CYP1A2
  • Clozapine