The iron link between malaria and invasive non-typhoid Salmonella infections

Trends Parasitol. 2013 May;29(5):220-7. doi: 10.1016/j.pt.2013.03.006. Epub 2013 Apr 16.

Abstract

Epidemiological studies have demonstrated an association between malaria and invasive non-typhoid Salmonella (NTS) infections, especially in children. We explore the role of iron as a possible cofactor in this association. Malarial disease, among others, is associated with enhanced erythrophagocytosis and inflammation, which increases the iron content of macrophages and thereby also the survival of Salmonella spp. within macrophages. Whether iron supplementation programs augment the risk of invasive NTS infections in malaria-endemic regions is an important global health issue that still needs to be determined.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Child
  • Coinfection
  • Erythrocytes / drug effects
  • Erythrocytes / parasitology
  • Homeostasis
  • Humans
  • Immunity / drug effects
  • Iron / metabolism*
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Macrophages / microbiology
  • Malaria, Falciparum / complications*
  • Malaria, Falciparum / immunology
  • Plasmodium falciparum / physiology*
  • Salmonella / drug effects*
  • Salmonella / growth & development
  • Salmonella / pathogenicity
  • Salmonella Infections / complications*
  • Salmonella Infections / immunology

Substances

  • Iron