Habitual coffee consumption inversely associated with metabolic syndrome-related biomarkers involving adiponectin

Nutrition. 2013 Jul-Aug;29(7-8):982-7. doi: 10.1016/j.nut.2013.01.011. Epub 2013 Apr 17.


Objectives: The goal of this cross-sectional study was to assess whether habitual coffee consumption shows beneficial association with metabolic syndrome (MetS) in adults.

Methods: The association of coffee consumption and MetS-related biomarkers including visceral fat area (VFA) and subcutaneous fat area (SFA), total serum adiponectin (T-Ad), low-molecular-weight serum adiponectin (LMW-AD), medium-molecular-weight serum adiponectin (MMW-Ad), and high-molecular-weight serum adiponectin (HMW-Ad) levels were analyzed among 364 Japanese men (36-61 y old) using two models of multivariate regression analyses; model 1 (adjusted for age, alcohol drinking, smoking, and walking status) and model 2 (adjusted for body mass index in addition to model 1 analysis). Participants were categorized into two groups according to their MetS risk score (raised blood pressure and hemoglobin A1c levels, and reduced high-density lipoprotein cholesterol levels).

Results: Both light (1-3 cups/d) and moderate (≥4 cups/d) coffee consumption showed significant inverse associations with VFA and VFA/SFA ratio (P < 0.0001). Moderate coffee consumption showed a favorable tendency toward these associations with T-Ad (P = 0.06) and HMW-Ad (P = 0.07) levels in model 1 analysis. In participants with lower MetS risk score (≤1), moderate coffee consumption showed significant associations with T-Ad and HMW-Ad levels (P < 0.05) in both analyses, whereas no significant associations of coffee consumption with adiponectin levels were seen in the men with higher MetS risk scores (≥2).

Conclusions: Habitual moderate coffee consumption shows significant inverse associations with MetS-related biomarkers possibly involving adiponectin, which is inversely related to visceral fat accumulation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiponectin / blood*
  • Adult
  • Biomarkers / blood*
  • Body Mass Index
  • Cholesterol / blood
  • Coffee*
  • Cross-Sectional Studies
  • Feeding Behavior
  • Glycated Hemoglobin / metabolism
  • Humans
  • Intra-Abdominal Fat / metabolism
  • Male
  • Metabolic Syndrome / blood*
  • Middle Aged
  • Molecular Weight
  • Multivariate Analysis
  • Regression Analysis
  • Risk Factors
  • Subcutaneous Fat / metabolism


  • Adiponectin
  • Biomarkers
  • Coffee
  • Glycated Hemoglobin A
  • Cholesterol