Anti-Sc1 in pregnancy

Transfusion. 1990 Jun;30(5):439-40. doi: 10.1046/j.1537-2995.1990.30590296379.x.


Anti-Sc1 was detected in a gravida-2 patient at 12 weeks' gestation. At 29 weeks, the antibody was found to be of the IgG3 subclass with a titer of 16, score 36, by the indirect antiglobulin test, and it produced 7 percent lysis by antibody-dependent cellular cytotoxicity (ADCC) assay, a finding that suggested an unaffected fetus. The titer remained constant throughout the pregnancy, as did the IgG subclass and activity in the ADCC assay. At delivery of the full-term infant, the cord hemoglobin was 13.5 g per dL and the direct antiglobulin test was positive (3+) with anti-IgG. The infant did not require transfusion. A sample taken 9 weeks after delivery showed 44 percent lysis in the ADCC assay. The anti-Sc1 titer was 32, score 65.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibody-Dependent Cell Cytotoxicity
  • Blood Group Antigens*
  • Blood Grouping and Crossmatching
  • Female
  • Humans
  • Pregnancy / blood*


  • Blood Group Antigens