18F-fluoride PET/CT aspect of an unusual case of Erdheim-Chester disease with histologic features of Langerhans cell histiocytosis

Clin Nucl Med. 2013 Jul;38(7):541-2. doi: 10.1097/RLU.0b013e318270830f.


We report the case of a 63-year-old woman with Erdheim-Chester disease (ECD) and histologic features of Langerhans cell histiocytosis, both extremely rare histiocytic proliferations responsible of skeletal and extraskeletal involvement. 18F-Fluoride PET/CT revealed multiple intense focal uptake scattered throughout the skeleton. We also performed an 18F-FDG PET/CT which point out visceral and vascular involvement. This case illustrates the interest of PET/CT in ECD, a rare polymorphus and systemic disease, and in our knowledge, this is the first reported illustration of 18F-fluoride PET/CT findings in this pathology.

Publication types

  • Case Reports

MeSH terms

  • Erdheim-Chester Disease / diagnostic imaging*
  • Erdheim-Chester Disease / pathology
  • Female
  • Fluorides*
  • Fluorine Radioisotopes*
  • Histiocytosis, Langerhans-Cell / diagnostic imaging*
  • Histiocytosis, Langerhans-Cell / pathology
  • Humans
  • Middle Aged
  • Multimodal Imaging
  • Positron-Emission Tomography*
  • Tomography, X-Ray Computed*
  • Whole Body Imaging


  • Fluorine Radioisotopes
  • Fluorides