Blood brain barrier function in vascular dementia

Acta Neurol Scand. 1990 Apr;81(4):318-22. doi: 10.1111/j.1600-0404.1990.tb01562.x.


To investigate blood-brain barrier (BBB) function measured as an albumin ratio (cerebrospinal fluid/serum) in vascular dementia (VD) samples from 53 patients and 30 healthy controls were analysed. The VD group showed a higher mean albumin ratio than controls (8.5 +/- 3.8 and 5.7 +/- 2.1, respectively). The albumin ratio did not correlate significantly with age, nor with individual clinical vascular factors. The results of the present study suggest that the altered BBB might be a consequence of small vessel disorder rather than evidence of infarcts.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Blood-Brain Barrier*
  • Dementia, Vascular / physiopathology*
  • Female
  • Humans
  • Male
  • Serum Albumin / pharmacokinetics*


  • Serum Albumin