Circadian clocks and metabolism

Handb Exp Pharmacol. 2013;(217):127-55. doi: 10.1007/978-3-642-25950-0_6.


Circadian clocks maintain periodicity in internal cycles of behavior, physiology, and metabolism, enabling organisms to anticipate the 24-h rotation of the Earth. In mammals, circadian integration of metabolic systems optimizes energy harvesting and utilization across the light/dark cycle. Disruption of clock genes has recently been linked to sleep disorders and to the development of cardiometabolic disease. Conversely, aberrant nutrient signaling affects circadian rhythms of behavior. This chapter reviews the emerging relationship between the molecular clock and metabolic systems and examines evidence that circadian disruption exerts deleterious consequences on human health.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Circadian Clocks / physiology*
  • Circadian Rhythm
  • Humans
  • Light
  • Mice
  • NAD / metabolism
  • Phenotype
  • Polymorphism, Genetic
  • Receptors, Cytoplasmic and Nuclear / physiology
  • Transcription, Genetic


  • Receptors, Cytoplasmic and Nuclear
  • NAD