Optical coherence tomography for advanced screening in the primary care office

J Biophotonics. 2014 Jul;7(7):525-33. doi: 10.1002/jbio.201200243. Epub 2013 Apr 18.


Optical coherence tomography (OCT) has long been used as a diagnostic tool in the field of ophthalmology. The ability to observe microstructural changes in the tissues of the eye has proved very effective in diagnosing ocular disease. However, this technology has yet to be introduced into the primary care office, where indications of disease are first encountered. We have developed a portable, handheld imaging probe for use in the primary care setting and evaluated its tissue site accessibility, ability to observe diseased tissue, and screening capabilities in in vivo human patients, particularly for pathologies related to the eye, ear and skin. Various stages of diabetic retinopathy were investigated using the handheld probe and early-stage diabetic retinopathy was flagged as abnormal from the OCT images. At such early stages of disease, it is difficult to observe abnormalities with the limited tools that are currently available to primary care physicians. These results indicate that OCT shows promise to transform from being a diagnostic technology in the medical and surgical specialities to a screening technology in the primary care office and at the front-line of healthcare.

Keywords: handheld; optical coherence tomography; portable; primary care medicine; screening.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Equipment Design
  • Equipment Failure Analysis
  • Humans
  • Image Enhancement / instrumentation
  • Image Interpretation, Computer-Assisted / instrumentation*
  • Mass Screening / instrumentation*
  • Miniaturization
  • Physicians' Offices*
  • Primary Health Care / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Tomography, Optical Coherence / instrumentation*