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, 19 (5), 364-6

Involvement of Protein Kinase B/Akt in Analgesic Effect of Dexmedetomidine on Neuropathic Pain

Involvement of Protein Kinase B/Akt in Analgesic Effect of Dexmedetomidine on Neuropathic Pain

Shuang-Shuang Li et al. CNS Neurosci Ther.

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chronic constriction injury (CCI)‐induced time course of paw withdrawal threshold (PWT) and changes of α2A‐AR and pAkt protein expression. (A) Time course of PWT in ipsilateral hind paw following CCI/sham surgery. (B, C) Western blot shows the changes of α2A‐AR and pAkt protein expression in ipsilateral spinal dorsal horn at different time points after CCI operation. The data are presented as mean ± SEM of six to eight rats per group. *< 0.05, **< 0.01, ***< 0.001 compared with sham group by two‐way RM ANOVA (A) or one‐way ANOVA (B, C).
Figure 2
Figure 2
Effects of intrathecal dexmedetomidine (DEX) on chronic constriction injury (CCI)‐induced pain behaviors and expression of pAkt in ipsilateral spinal dorsal horn. DEX was given at day 7 after CCI surgery. (A) Time course of paw withdrawal threshold (PWT) to stimulation in ipsilateral hind paw before and 30, 60, 90, and 120 min after intrathecal DEX/vehicle. (B) Western blot shows the expression of pAkt in ipsilateral spinal dorsal horn at 60 min after intrathecal DEX/vehicle. The data are presented as mean ± SEM of six to eight rats per group. *< 0.05, **< 0.01, ***< 0.001 compared with vehicle group by two‐way RM ANOVA (A) or t‐test (B).

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