Abstract
We treated 3 patients with newly diagnosed aggressive oligodendroglioma with chemotherapy prior to radiotherapy and observed responses. All had residual or progressive tumor following initial surgery. We used a combination called PCV-3 because recurrent anaplastic oligodendroglioma responds predictably to this regimen. Chemotherapy for response induction followed by radiotherapy for consolidation is feasible and effective initial treatment for this tumor.
Publication types
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Case Reports
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Antineoplastic Combined Chemotherapy Protocols
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Brain Neoplasms / diagnostic imaging
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Brain Neoplasms / drug therapy*
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Brain Neoplasms / radiotherapy
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Female
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Humans
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Lomustine / adverse effects
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Lomustine / therapeutic use*
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Male
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Middle Aged
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Oligodendroglioma / diagnostic imaging
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Oligodendroglioma / drug therapy*
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Oligodendroglioma / radiotherapy
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Procarbazine / adverse effects
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Procarbazine / therapeutic use*
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Tomography, X-Ray Computed
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Vincristine / adverse effects
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Vincristine / therapeutic use*
Substances
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Procarbazine
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Vincristine
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Lomustine