BRAF(V600E) mutation is a negative prognosticator in pediatric ganglioglioma

Acta Neuropathol. 2013 Jun;125(6):901-10. doi: 10.1007/s00401-013-1120-y. Epub 2013 Apr 23.


Gangliogliomas are typically low-grade neuroepithelial tumors seen in the pediatric and young adult populations. Despite their often bland histologic appearance, these tumors recur with varying frequencies; however, little data exist that adequately predict ganglioglioma recurrence in children. To identify potential histopathologic features predictive of recurrence-free survival, a series of 53 patients with World Health Organization (WHO) grade I gangliogliomas were evaluated, representing the largest cohort of pediatric gangliogliomas with accompanying histopathologic and survival data. Fifteen patients (28 %) exhibited disease recurrence during the study period. BRAF(V600E) immunohistochemistry was performed on 47 of these tumors. Histopathologic features associated with shorter recurrence-free survival included an absence of oligodendroglial morphology, higher glial cell density, microvascular proliferation, and the presence of a high lymphoplasmacytic inflammatory infiltrate. Eighteen tumors (38.3 %) had positive BRAF(V600E) staining, which was associated with shorter recurrence-free survival. Collectively, the combined use of histopathologic and molecular features to stratify grade I gangliogliomas into low and high-risk groups provides important information relevant to the management of children and young adults with these rare tumors.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Brain Neoplasms / metabolism*
  • Brain Neoplasms / mortality
  • Brain Neoplasms / pathology*
  • Child
  • Child, Preschool
  • Cohort Studies
  • Disease-Free Survival
  • Female
  • Ganglioglioma / metabolism*
  • Ganglioglioma / mortality
  • Ganglioglioma / pathology*
  • Humans
  • Infant
  • Male
  • Mutant Proteins / metabolism*
  • Proto-Oncogene Proteins B-raf / metabolism*
  • Survival Rate
  • Young Adult


  • Mutant Proteins
  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf