Sticking together the Crumbs - an unexpected function for an old friend

Nat Rev Mol Cell Biol. 2013 May;14(5):307-14. doi: 10.1038/nrm3568.


Cell polarity and cell-cell junctions have pivotal roles in organizing cells into tissues and in mediating cell-cell communication. The transmembrane protein Crumbs has a well-established role in the maintenance of epithelial polarity, and it can also regulate signalling via the Notch and Hippo pathways to influence tissue growth. The functions of Crumbs in epithelial polarity and Hippo-mediated growth depend on its short intracellular domain. Recent evidence now points to a conserved and fundamental role for the extracellular domain of Crumbs in mediating homophilic Crumbs-Crumbs interactions at cell-cell junctions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Communication / physiology
  • Cell Polarity / physiology*
  • Epithelial Cells / cytology
  • Epithelial Cells / metabolism
  • Epithelial Cells / physiology
  • Humans
  • Intercellular Junctions / metabolism
  • Intercellular Junctions / physiology*
  • Membrane Proteins / metabolism
  • Membrane Proteins / physiology*
  • Nerve Tissue Proteins / metabolism
  • Nerve Tissue Proteins / physiology*


  • Membrane Proteins
  • Nerve Tissue Proteins