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. 2013 Mar;10(1):75-81.
doi: 10.3969/j.issn.1671-5411.2013.01.012.

Ageing and Brugada Syndrome: Considerations and Recommendations

Free PMC article

Ageing and Brugada Syndrome: Considerations and Recommendations

Pieter G Postema et al. J Geriatr Cardiol. .
Free PMC article


Brugada syndrome is an inherited disease associated with an increased risk of lethal ventricular arrhythmias. Such arrhythmias stem from innate disruptions in cardiac electrophysiology. Typically, such arrhythmias occur in the third or fourth decade of life. However, Brugada syndrome may also affect geriatric patients. In this paper, we focus on the ageing patient with Brugada syndrome, and specifically, on the interaction between Brugada syndrome and the more usually acquired clinical problems that may occur with increasing age, such as the use of cardiovascular and non-cardiovascular drugs, or the need for surgery. Such common conditions may also disrupt cardiac electrophysiology, thereby conferring added risk for Brugada syndrome patients. We present some considerations and recommendations that may serve as guidance to address these complexities.

Keywords: Aging; Arrhythmias; Brugada syndrome; Geriatrics; Risk stratification; Sudden death.


Figure 1.
Figure 1.. Example of the development of a type-1 Brugada ECG during an ajmaline provocation test.
Please note the absence of abnormal STT segments at baseline and the development of typical type-1, coved type, STT segments in the right precordial leads in concert with clear conduction delay upon ajmaline provocation. Please also note that the V3 lead is placed one intercostal space above V1 (V1 ic3) and V5 is placed one intercostal space above V2 (V2 ic3) to increase sensitivity.

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