Intracellular pathogen detection by RIG-I-like receptors

Adv Immunol. 2013;117:99-125. doi: 10.1016/B978-0-12-410524-9.00004-9.

Abstract

The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 trigger innate immune responses against viral infections that serve to limit virus replication and to stimulate adaptive immunity. RLRs are cytosolic sensors for virus-derived RNA and thus responsible for intracellular immune surveillance against infection. RLR signaling requires the adapter protein MAVS to induce type I interferon, interferon-stimulated genes, and proinflammatory cytokines. This review focuses on the molecular and cell biological requirements for RLR signal transduction.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacterial Infections / immunology
  • Bacterial Infections / metabolism
  • Bacterial Infections / virology*
  • DEAD Box Protein 58
  • DEAD-box RNA Helicases / metabolism*
  • DEAD-box RNA Helicases / physiology
  • Host-Pathogen Interactions / immunology*
  • Humans
  • Interferon-Induced Helicase, IFIH1
  • Intracellular Fluid / immunology
  • Intracellular Fluid / metabolism
  • Intracellular Fluid / microbiology*
  • Intracellular Fluid / virology*
  • Membrane Proteins / metabolism
  • Membrane Proteins / physiology
  • Nerve Tissue Proteins / metabolism
  • Nerve Tissue Proteins / physiology
  • RNA Helicases / metabolism
  • RNA Helicases / physiology
  • RNA Virus Infections / immunology*
  • RNA Virus Infections / metabolism
  • RNA Virus Infections / virology
  • Receptors, Pattern Recognition / metabolism
  • Receptors, Pattern Recognition / physiology
  • Signal Transduction / immunology

Substances

  • Membrane Proteins
  • Nerve Tissue Proteins
  • Receptors, Pattern Recognition
  • Robo3 protein, mouse
  • Dhx58 protein, mouse
  • DDX58 protein, human
  • IFIH1 protein, human
  • DEAD Box Protein 58
  • DEAD-box RNA Helicases
  • Interferon-Induced Helicase, IFIH1
  • RNA Helicases