Protein energy wasting and transplantation

J Ren Nutr. 2013 May;23(3):246-9. doi: 10.1053/j.jrn.2013.02.004.


In patients with advanced renal failure or those undergoing dialysis, protein energy wasting (PEW) is a frequently occurring complication that is associated with increased cardiovascular morbidity and mortality. Fewer data are available for patients after transplantation. In this article, the available data on nutritional status after kidney transplantation is reviewed. It was also found that signs of PEW and microinflammation in patients undergoing kidney transplantation are associated with both impaired transplantation outcomes and decreased patient survival. Data are lacking on nutritional support and outcomes after transplantation. Only 1 study revealed a possible relationship between healthier eating habits and better outcomes in patients who have undergone transplantation. More data support the notion that sufficient physical exercise improves graft survival and patient outcome after kidney transplantation. Future studies on nutritional support in patients with signs of PEW and microinflammation immediately after transplantation could reveal whether such a strategy improves renal and patient outcomes.

Publication types

  • Review

MeSH terms

  • Humans
  • Kidney Failure, Chronic / complications*
  • Kidney Failure, Chronic / physiopathology
  • Kidney Failure, Chronic / surgery
  • Kidney Transplantation
  • Nutritional Status
  • Protein-Energy Malnutrition / etiology*
  • Protein-Energy Malnutrition / physiopathology
  • Renal Dialysis / adverse effects
  • Treatment Outcome