Cathecol-O-methyl transferase Val158Met genotype is not a risk factor for conversion disorder

Genet Mol Res. 2013 Mar 19;12(1):852-8. doi: 10.4238/2013.March.19.1.


Alterations in catechol-O-methyltransferase (COMT) activity are involved in various types of neurological disorders. We examined a possible association between the COMT Val158Met polymorphism and conversion disorder in a study of 48 patients with conversion disorder and 48 control patients. In the conversion disorder group, 31 patients were Val/Met heterozygotes, 15 patients were Val/Val homozygotes and 2 patients were Met/Met homozygotes. In the control group, 32 patients were Val/Met heterozygotes and 16 patients were Val/Val homozygotes. There was no significant difference between the groups. We conclude that the COMT Val158Met genotype is quite common in Turkey and that it is not a risk factor for conversion disorder in the Turkish population.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Amino Acid Substitution*
  • Catechol O-Methyltransferase / genetics*
  • Chi-Square Distribution
  • Conversion Disorder / enzymology
  • Conversion Disorder / genetics*
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease / genetics
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Genetic*
  • Risk Factors
  • Turkey
  • Young Adult


  • Catechol O-Methyltransferase