Glucose variability

Diabetes. 2013 May;62(5):1398-404. doi: 10.2337/db12-1396.


The proposed contribution of glucose variability to the development of the complications of diabetes beyond that of glycemic exposure is supported by reports that oxidative stress, the putative mediator of such complications, is greater for intermittent as opposed to sustained hyperglycemia. Variability of glycemia in ambulatory conditions defined as the deviation from steady state is a phenomenon of normal physiology. Comprehensive recording of glycemia is required for the generation of any measurement of glucose variability. To avoid distortion of variability to that of glycemic exposure, its calculation should be devoid of a time component.

MeSH terms

  • Blood Glucose / analysis*
  • Circadian Rhythm
  • Diabetes Complications / etiology
  • Diabetes Complications / prevention & control
  • Diabetes Mellitus / blood
  • Diabetes Mellitus / diet therapy
  • Diabetes Mellitus / drug therapy
  • Diabetes Mellitus / therapy*
  • Diet, Diabetic
  • Humans
  • Hyperglycemia / physiopathology*
  • Hyperglycemia / prevention & control
  • Hypoglycemic Agents / therapeutic use
  • Oxidative Stress
  • Risk Assessment


  • Blood Glucose
  • Hypoglycemic Agents