Management of drug induced sexual dysfunction in male rats by ethyl acetate fraction of onion

Acta Pol Pharm. Mar-Apr 2013;70(2):317-22.


The present study aimed to investigate the effect of ethyl acetate fraction of A. cepa bulb on mating behavior in paroxetine-induced sexually dysfunction male rats. Sexual dysfunctions such as decreased libido, delayed orgasm, difficulties in maintaining an erection, and inhibition of ejaculation are common side effects of paroxetine. A. cepa bulb ethyl acetate fraction (200 mg/kg) was administered orally in paroxetine-induced sexually impaired male rats for 7 days. At the end of 7th day, mount frequency (MF), intromission frequency (IF), ejaculatory frequency (EF), mount latency (ML), intromission latency (IL), ejaculatory latency (EL) and post-ejaculatory interval (PEI) were the parameters observed. Results showed that in relation to the paroxetine treated group, ethyl acetate fraction, significantly restored the normal sexual behavior as evident from increased MF, IF, EF and reduced ML, IL, EL and PEI.

MeSH terms

  • Acetates / chemistry*
  • Animals
  • Disease Models, Animal
  • Ejaculation / drug effects
  • Female
  • Libido / drug effects
  • Male
  • Onions* / chemistry
  • Paroxetine
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Plant Roots
  • Plants, Medicinal
  • Rats
  • Rats, Wistar
  • Reaction Time
  • Sexual Behavior, Animal / drug effects
  • Sexual Dysfunction, Physiological / chemically induced
  • Sexual Dysfunction, Physiological / drug therapy*
  • Sexual Dysfunction, Physiological / physiopathology
  • Sexual Dysfunction, Physiological / psychology
  • Solvents / chemistry*
  • Time Factors


  • Acetates
  • Plant Extracts
  • Solvents
  • Paroxetine
  • ethyl acetate