Clostridial myonecrosis, haemolytic anaemia, hepatopathy, osteitis and transient hypertrophic cardiomyopathy after intramuscular injection in a Thoroughbred gelding

Aust Vet J. 2013 May;91(5):204-8. doi: 10.1111/avj.12021. Epub 2013 Mar 11.

Abstract

A 9-year-old Thoroughbred gelding was presented for swelling over the left neck and inappetence. There was recent history of intramuscular administration of flunixin meglumine into the left neck. On examination, there was evidence of focal myositis, anaemia, haemolysis and pigmenturia. Culture of aspirated fluid from the left side of the neck produced a heavy growth of a Clostridium species. Complications of infection included haemolytic anaemia, hepatopathy, osteitis and transient hypertrophic cardiomyopathy. Treatment included intravenous fluid therapy, antibiotics, anti-inflammatory drugs, blood transfusion and surgical debridement. There was complete resolution of clinical, haematological, biochemical and echocardiographic abnormalities, and the horse returned to ridden work. This report highlights the complications that can arise from clostridial myonecrosis, including the effect on the myocardium.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Anemia, Hemolytic / etiology
  • Anemia, Hemolytic / microbiology
  • Anemia, Hemolytic / veterinary
  • Animals
  • Cardiomyopathy, Hypertrophic / etiology
  • Cardiomyopathy, Hypertrophic / microbiology
  • Cardiomyopathy, Hypertrophic / veterinary
  • Clostridium Infections / complications
  • Clostridium Infections / veterinary*
  • Horse Diseases / etiology*
  • Horse Diseases / microbiology
  • Horses
  • Injections, Intramuscular / adverse effects
  • Injections, Intramuscular / veterinary*
  • Liver Diseases / etiology
  • Liver Diseases / microbiology
  • Liver Diseases / veterinary
  • Male
  • Osteitis / etiology
  • Osteitis / microbiology
  • Osteitis / veterinary