The class III phosphatidylinositol 3-kinase PIK3C3/VPS34 regulates endocytosis and autophagosome-autolysosome formation in podocytes

Autophagy. 2013 Jul;9(7):1097-9. doi: 10.4161/auto.24634. Epub 2013 Apr 15.


Phosphatidylinositol phosphates are key regulators of vesicle identity, formation and trafficking. In mammalian cells, the evolutionarily conserved class III PtdIns 3-kinase PIK3C3/VPS34 is part of a large multiprotein complex that catalyzes the localized phosphorylation of phosphatidylinositol to phosphatidylinositol-3-phosphate (PtdIns3P). We demonstrate that PIK3C3 has a key function in vesicular trafficking, endocytosis and autophagosome-autolysosome formation in the highly specialized glomerular podocytes.

Keywords: Pik3c3; Vps34; autophago-lysosomal formation; autophagy; endocytosis; glomerulosclerosis; phosphoinositide 3-kinase; podocyte; proteinuria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autophagy*
  • Class III Phosphatidylinositol 3-Kinases / deficiency
  • Class III Phosphatidylinositol 3-Kinases / metabolism*
  • Drosophila melanogaster / cytology
  • Endocytosis*
  • Humans
  • Lysosomes / metabolism*
  • Mice
  • Models, Biological
  • Phagosomes / metabolism*
  • Podocytes / cytology*
  • Podocytes / enzymology*


  • Class III Phosphatidylinositol 3-Kinases