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. 2013 Apr;46(4):181-7.
doi: 10.5483/bmbrep.2013.46.4.033.

Caloric Restriction and Its Mimetics

Free PMC article

Caloric Restriction and Its Mimetics

Shin-Hae Lee et al. BMB Rep. .
Free PMC article


Caloric restriction is the most reliable intervention to prevent age-related disorders and extend lifespan. The reduction of calories by 10-30% compared to an ad libitum diet is known to extend the longevity of various species from yeast to rodents. The underlying mechanisms by which the benefits of caloric restriction occur have not yet been clearly defined. However, many studies are being conducted in an attempt to elucidate these mechanisms, and there are indications that the benefits of caloric restriction are related to alteration of the metabolic rate and the accumulation of reactive oxygen species. During molecular signaling, insulin/insulin-like growth factor signaling, target of rapamycin pathway, adenosine monophosphate activated protein kinase signaling, and Sirtuin are focused as underlying pathways that mediate the benefits of caloric restriction. Here, we will review the current status of caloric restriction.

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    1. Fontana L., Partridge L., Longo V. D. Extending healthy life span--from yeast to humans. Science. (2010);328:321–326. doi: 10.1126/science.1172539. - DOI - PMC - PubMed
    1. Masoro E. J. Overview of caloric restriction and ageing. Mech. Ageing Dev. (2005);126:913–922. doi: 10.1016/j.mad.2005.03.012. - DOI - PubMed
    1. Speakman J. R., Mitchell S. E. Caloric restriction. Mol. Aspects Med. (2011);32:159–221. doi: 10.1016/j.mam.2011.07.001. - DOI - PubMed
    1. Fontana L., Weiss E. P., Villareal D. T., Klein S., Holloszy J. O. Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. Aging Cell. (2008);7:681–687. doi: 10.1111/j.1474-9726.2008.00417.x. - DOI - PMC - PubMed
    1. Orentreich N., Matias J. R., DeFelice A., Zimmerman J. A. Low methionine ingestion by rats extends life span. J. Nutr. (1993);123:269–274. - PubMed

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