NLRP7 and related inflammasome activating pattern recognition receptors and their function in host defense and disease

Microbes Infect. Jul-Aug 2013;15(8-9):630-9. doi: 10.1016/j.micinf.2013.04.001. Epub 2013 Apr 22.

Abstract

Host defense requires the maturation and release of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 and the induction of pyroptotic cell death, which depends on the activation of inflammatory Caspases within inflammasomes by innate immune cells. Several cytosolic pattern recognition receptors (PRRs) have been implicated in this process in response to infectious and sterile agonists. Here we summarize the current knowledge on inflammasome-organizing PRRs, emphasizing the recently described NLRP7, and their implications in human disease.

Keywords: AIM2-like receptor; Hydatidiform mole; Inflammasome; Inflammation; Nod-like receptor; Pattern recognition receptor.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / immunology*
  • Adaptor Proteins, Signal Transducing / metabolism
  • Animals
  • Communicable Diseases / immunology*
  • Communicable Diseases / pathology*
  • Humans
  • Inflammasomes / immunology*
  • Inflammasomes / metabolism
  • Metabolic Diseases / immunology*
  • Metabolic Diseases / pathology*
  • Models, Biological
  • Receptors, Pattern Recognition / immunology*
  • Receptors, Pattern Recognition / metabolism

Substances

  • Adaptor Proteins, Signal Transducing
  • Inflammasomes
  • NLRP7 protein, human
  • Receptors, Pattern Recognition