RSVSim: an R/Bioconductor package for the simulation of structural variations

Bioinformatics. 2013 Jul 1;29(13):1679-81. doi: 10.1093/bioinformatics/btt198. Epub 2013 Apr 25.


RSVSim is a tool for the simulation of deletions, insertions, inversions, tandem duplications and translocations of various sizes in any genome available as FASTA-file or data package in R. The structural variations can be generated randomly, based on user-supplied genomic coordinates or associated to various kinds of repeats. The package further comprises functions to estimate the distribution of structural variation sizes from real datasets.

Availability: RSVSim is implemented in R and available at A vignette with detailed descriptions of the functions and examples is included.

MeSH terms

  • Chromosome Breakpoints
  • Computer Simulation
  • Genome
  • Genomic Structural Variation*
  • Genomics / methods
  • Software*