Transmetatarsal amputation in the setting of antiphospholipid antibody syndrome

J Foot Ankle Surg. 2013 May-Jun;52(3):383-8. doi: 10.1053/j.jfas.2013.02.011.


Antiphospholipid syndrome is a hypercoagulable disease that can present foot and ankle surgeons with a unique challenge in treating patients who present with thrombosis and ischemia despite having normal pedal pulses. Appropriate perioperative management is imperative in these patients, because limb- and life-threatening complications can occur postoperatively, despite aggressive anticoagulation. We present the case of a 46-year-old male who underwent a transmetatarsal amputation and, despite aggressive therapy, developed a myriad of complications postoperatively. At 10 months postoperatively, the patient was doing well in an accommodative orthotic with minimal pain while receiving continued aggressive therapy and follow-up examinations by a number of specialists to treat his antiphospholipid syndrome.

Publication types

  • Case Reports

MeSH terms

  • Amputation, Surgical / methods*
  • Antiphospholipid Syndrome / complications*
  • Arterial Occlusive Diseases / etiology
  • Arterial Occlusive Diseases / surgery*
  • Humans
  • Ischemia / etiology
  • Ischemia / surgery*
  • Leg Ulcer / etiology
  • Leg Ulcer / surgery*
  • Lower Extremity / blood supply*
  • Male
  • Metatarsal Bones / surgery*
  • Middle Aged