The phosphatase PP2A links glutamine to the tumor suppressor p53

Mol Cell. 2013 Apr 25;50(2):157-8. doi: 10.1016/j.molcel.2013.04.010.


In this issue of Molecular Cell, Reid et al. (2013) show that glutamine withdrawal causes PP2A-mediated activation of p53 through its regulator EDD, linking levels of a critical metabolite to an important regulator of cell survival and proliferation.

Publication types

  • Comment