Mycobacterial lineages causing pulmonary and extrapulmonary tuberculosis, Ethiopia

Emerg Infect Dis. 2013 Mar;19(3):460-3. doi: 10.3201/eid1903.120256.

Abstract

Molecular typing of 964 specimens from patients in Ethiopia with lymph node or pulmonary tuberculosis showed a similar distribution of Mycobacterium tuberculosis strains between the 2 disease manifestations and a minimal role for M. bovis. We report a novel phylogenetic lineage of M. tuberculosis strongly associated with the Horn of Africa.

Keywords: Ethiopia; Mycobacterium bovis; Mycobacterium tuberculosis; TB lymphadenitis; Tuberculosis and other mycobacteria; bacteria; bovine; cervical lymph nodes; extrapulmonary tuberculosis; lineage; lymph nodes; pulmonary tuberculosis; tuberculosis; zoonoses; zoonotic transmission.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cluster Analysis
  • Ethiopia
  • Genes, Bacterial
  • Humans
  • Lymph Nodes / microbiology
  • Multilocus Sequence Typing
  • Mycobacterium tuberculosis / genetics*
  • Mycobacterium tuberculosis / isolation & purification
  • Neck
  • Phylogeny
  • Polymorphism, Single Nucleotide
  • Tuberculosis, Lymph Node / microbiology*
  • Tuberculosis, Pulmonary / microbiology*