Malignant transformation in the course of a dentigerous cyst: a problem for a clinician and a pathologist. Considerations based on a case report

Pol J Pathol. 2013 Apr;64(1):64-8. doi: 10.5114/pjp.2013.34606.


Primary intraosseous squamous cell carcinoma (PIOSCC) is a rarely reported neoplasm resulting from malignant transformation of a dentigerous cyst of the mandible or maxilla. Until 2010, only 116 cases had been described. The diagnosis of PIOSCC is difficult because of non-specific symptoms. A case of a 66-year-old patient with PIOSCC arising from a dentigerous cyst of the mandible is presented. Both pathologists and clinicians should be aware of the probability of malignant transformation of dentigerous cysts during the two-stage treatment. The patient should be subject to regular clinical and radiographic examination.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Biopsy
  • Carcinoma, Squamous Cell / diagnostic imaging
  • Carcinoma, Squamous Cell / etiology
  • Carcinoma, Squamous Cell / pathology*
  • Carcinoma, Squamous Cell / surgery
  • Cell Transformation, Neoplastic*
  • Dentigerous Cyst / complications*
  • Dentigerous Cyst / diagnostic imaging
  • Dentigerous Cyst / pathology
  • Dentigerous Cyst / surgery
  • Diagnosis, Differential
  • Humans
  • Male
  • Mandible / pathology
  • Mandibular Neoplasms / diagnostic imaging
  • Mandibular Neoplasms / etiology
  • Mandibular Neoplasms / pathology*
  • Mandibular Neoplasms / surgery
  • Maxilla / pathology
  • Poland
  • Radiography, Panoramic