Neonatal RIFLE

Nephrol Dial Transplant. 2013 Sep;28(9):2211-4. doi: 10.1093/ndt/gft074. Epub 2013 Apr 25.


A standardized classification of acute kidney injury (AKI) has recently been proposed with the RIFLE (Risk, Injury, Failure, Loss of function, End-stage kidney disease) score. Such definition/classification has been applied both in adult and in paediatric patients. Neonatal definition of AKI likely results as a challenging task due to the peculiar renal pathophysiology of newborn critically ill patients. Their so-called 'immature kidneys' require careful management and neonatal AKI is frequently complicated by unfavourable outcomes. A recent attempt to implement the RIFLE score with a neonatal modification might lead to improvement on the knowledge of AKI incidence and epidemiology.

Keywords: RIFLE score; acute kidney injury; classification; definition.

MeSH terms

  • Acute Kidney Injury / classification
  • Acute Kidney Injury / diagnosis
  • Acute Kidney Injury / epidemiology*
  • Adult
  • Critical Illness*
  • Humans
  • Incidence
  • Infant, Newborn
  • Prognosis