Acute renal failure of leptospirosis: nonoliguric and hypokalemic forms

Nephron. 1990;55(2):146-51. doi: 10.1159/000185943.


Acute renal failure induced by leptospirosis was studied in 56 patients. A higher frequency of nonoliguric renal failure was observed with lower morbidity and mortality rates than in oliguric forms. In addition, 45% of the patients in this series were hypokalemic, and no hyperkalemic patients were seen. A prospective study in 11 patients showed an initially elevated urinary fractional potassium excretion that fell simultaneously with the high urinary fractional sodium excretion and the urinary K/Na ratio, suggesting an increased distal potassium secretion due to an increased distal sodium delivery consequent to functional impairment of the proximal reabsorption of sodium.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Kidney Injury / classification
  • Acute Kidney Injury / etiology*
  • Acute Kidney Injury / metabolism
  • Adolescent
  • Adult
  • Child
  • Female
  • Furosemide / therapeutic use
  • Humans
  • Hypokalemia / etiology
  • Leptospirosis / complications*
  • Male
  • Middle Aged
  • Oliguria / drug therapy
  • Oliguria / etiology
  • Potassium / blood
  • Potassium / urine
  • Sodium / urine


  • Furosemide
  • Sodium
  • Potassium