Palladium-catalyzed ortho-acylation of 2-aryl pyridine derivatives using arylmethyl amines as new acyl sources

Qian Zhang; Fan Yang; Yangjie Wu

doi:10.1039/c3cc42106f

Palladium-catalyzed ortho-acylation of 2-aryl pyridine derivatives using arylmethyl amines as new acyl sources

Chem Commun (Camb). 2013 Aug 7;49(61):6837-9. doi: 10.1039/c3cc42106f.

Authors

Qian Zhang¹, Fan Yang, Yangjie Wu

Affiliation

¹ The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Zhengzhou University, Zhengzhou 450052, People's Republic of China.

PMID: 23629481
DOI: 10.1039/c3cc42106f

Abstract

A facile and efficient protocol for palladium-catalyzed ortho-acylation of 2-aryl pyridines was developed. Note that this acylation utilized arylmethyl amines as new, cheap and readily available acylation reagents and exhibited high regioselectivity for 2-aryl pyridines bearing a meta-substituent in the aryl ring moiety.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acylation
Amines / chemistry*
Catalysis
Crystallography, X-Ray
Models, Molecular
Molecular Structure
Organometallic Compounds / chemistry*
Palladium / chemistry*
Pyridines / chemical synthesis*
Pyridines / chemistry

Substances

Amines
Organometallic Compounds
Pyridines
Palladium
pyridine