IL-11/IL11RA receptor mediated signaling: a web accessible knowledgebase

Cell Commun Adhes. 2013 Aug;20(3-4):81-6. doi: 10.3109/15419061.2013.791683. Epub 2013 Apr 30.


Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. It plays a significant role in the synthesis and maturation of hematopoietic cells, inhibition of adipogenesis, regulation of embryo implantation, and trophoblasts invasion. Although IL-11 signaling has been described in several biological processes, a centralized resource documenting these molecular reactions induced by IL-11 is not publicly available. In the current study, we have manually annotated the molecular reactions and interactions induced by IL-11 from literature available. We have documented 40 unique molecules involved in 18 protein-protein interactions, 26 enzyme-substrate reactions, 7 translocation events, and 4 activation/ inhibition reactions. We have also annotated 23 genes reported to be differentially regulated under IL-11 stimulation. We have enabled the data availability in standard exchange formats from 'NetPath', a repository for signaling pathways. We believe that this will help in the identification of potential therapeutic targets in IL-11-associated disorders.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Interleukin-11 / metabolism*
  • Interleukin-11 Receptor alpha Subunit / metabolism*
  • Internet*
  • Knowledge Bases*
  • Signal Transduction*


  • IL11 protein, human
  • IL11RA protein, human
  • Interleukin-11
  • Interleukin-11 Receptor alpha Subunit