The diagnostic and prognostic significance of SCUBE1 levels in Crimean-Congo hemorrhagic fever

Int J Infect Dis. 2013 Nov;17(11):e1042-5. doi: 10.1016/j.ijid.2013.03.014. Epub 2013 Apr 28.


Background: The new biochemical marker, signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1), is secreted and cell surface glycoprotein expressed during early embryogenesis. The protein is found in platelet and endothelial cells. Crimean-Congo hemorrhagic fever (CCHF), which is caused by a tick-borne virus belonging to the Bunyaviridae family, may present with a mild clinical course or may exhibit a severe profile with potentially fatal hemorrhaging. The aim of this study was to determine the diagnostic and prognostic significance of SCUBE1 levels in CCHF.

Methods: This study was conducted with patients with CCHF. SCUBE1 levels in patients with CCHF were determined using an ELISA.

Results: SCUBE1 titers of CCHF patients were significantly higher compared to those of the control group (p=0.0001). SCUBE1 levels of patients with hemorrhage were significantly higher than those of patients without hemorrhage (p=0.0001). SCUBE1 values of patients who died were significantly higher than those of the survivors (p=0.012).

Conclusions: SCUBE1 levels are a new biomarker that can be used in the differential diagnosis and monitoring of patients hospitalized with suspected CCHF. These levels are also significant as potential predictors of mortality.

Keywords: Biomarker; CCHF; Hemorrhagic fever; Prognostic significance; SCUBE1.

MeSH terms

  • Adult
  • Aged
  • Biomarkers / blood
  • Calcium-Binding Proteins
  • Female
  • Hemorrhagic Fever Virus, Crimean-Congo*
  • Hemorrhagic Fever, Crimean / blood*
  • Hemorrhagic Fever, Crimean / diagnosis*
  • Hemorrhagic Fever, Crimean / mortality
  • Humans
  • Male
  • Membrane Proteins / blood*
  • Middle Aged
  • Prognosis
  • ROC Curve
  • Reference Values
  • Retrospective Studies


  • Biomarkers
  • Calcium-Binding Proteins
  • Membrane Proteins
  • SCUBE1 protein, human