Real-time handheld multispectral optoacoustic imaging

Opt Lett. 2013 May 1;38(9):1404-6. doi: 10.1364/OL.38.001404.


Multispectral optoacoustic tomography (MSOT) of functional and molecular contrast has the potential to find broad deployment in clinical practice. We have developed the first handheld MSOT imaging device with fast wavelength tuning achieving a frame rate of 50 Hz. In this Letter, we demonstrate its clinical potential by dynamically resolving multiple disease-relevant tissue chromophores, including oxy-/deoxyhemoglobin, and melanin, in human volunteers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Hemoglobins / metabolism
  • Humans
  • Infrared Rays
  • Oxyhemoglobins / metabolism
  • Photoacoustic Techniques / instrumentation*
  • Time Factors
  • Tomography, Optical / instrumentation*
  • Wrist / blood supply


  • Hemoglobins
  • Oxyhemoglobins
  • deoxyhemoglobin